Evaluation of sperm damage: beyond the World Health Organization criteria.
نویسندگان
چکیده
Current knowledge of the molecular basis of male infertility that is associated with oxidative stress, apoptosis, and chromatin damage calls for changes in the laboratory assessment of the fertility potential of semen samples.
منابع مشابه
P-19: Effect of Three Sperm Preparation Methods on Sperm DNA Integrity and Oocyte Fertilization Rate
Background: Techniques of sperm preparation require centrifugation to separate spermatozoa from the seminal plasma. The centrifugation can induce damage to the spermatozoa and increase reactive oxygen species(ROS) productionspecially in leukospermic speciemens that are associated with impaired function and fertilizing capacity. However in ICSI, fertilization can occure with damage DNA sperm but...
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Introduction: Sperm-specific phospholipase C zeta (PLCζ) protein is expressed during spermatogenesis and plays a main role during oocyte activation. In this study, the expression of sperm PLCζ protein and DNA damage in fertile and infertile men was assessed. Methods: In this case-control study, semen samples were collected from 15 fertile and 10 infertile men candidated for intra-cyt...
متن کاملP-12: Effect of Centrifugation on Levels of Stress Oxidative of Human Spermatozoa
Background: Cryopreservation has adverse effect on human spermatozoa via exposure to physical and chemical stress that may lead to alter in reactive oxygen species (ROS) levels. During sperm preparation or cryopreservation, centrifugation as a physical stress may effect on sperm quality probably with stress oxidative production and membrane damage. Therefore the aim of this study was to evaluat...
متن کاملClinical significance of the low normal sperm morphology value as proposed in the fifth edition of the WHO Laboratory Manual for the Examination and Processing of Human Semen.
The very low cut-off value for sperm morphology of 4% morphologically normal spermatozoa, as proposed in the new edition of the World Health Organization (WHO) manual on semen analysis, is in agreement with recently published values and reflects the trend of a decline in reported mean values for normal sperm morphology. The reduced value for morphologically normal spermatozoa over the years may...
متن کاملSignificance of sperm characteristics in the evaluation of male infertility.
OBJECTIVE To compare sperm characteristics among: patients undergoing infertility evaluation, patients with male factor infertility (MFI), healthy sperm donors, and men with proven fertility; to examine the overlap of sperm characteristics in all four of these groups; and to identify good discriminators of fertility versus infertility among sperm characteristics. DESIGN Retrospective study. ...
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عنوان ژورنال:
- Fertility and sterility
دوره 90 3 شماره
صفحات -
تاریخ انتشار 2008